CJC-1295 is a synthetically modified and tetrasubstituted form of Growth Hormone-Releasing Hormone (GHRH1-29). The substitution of four amino acids from the core moiety makes CJC-1295 peptide more resistant to cleaving by proteolytic enzymes.
Research supports that CJC 1295 stimulates GH secretion, and can lead to a more youthful and amplified release of GH and IGF-1 with minimal effect on cortisol and prolactin levels. The benefits of CJC 1295 therapy include increased protein synthesis, improved recovery, reduced body fat and immune system support.
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How it works?
Studies of CJC-1295 peptide using animal test subjects shows how this peptide works by interacting with the Growth Hormone (GH), Insulin-like Growth Factor 1 (IGF-1), and Dipeptidyl Amino Peptidase-IV (DPP-IV) enzyme.
DPP-IV is an antigenic enzyme involved for things such as signal transduction, apoptosis or programmed cell death, and immune system regulation. It has also a direct effect on the half-life of Growth Hormone (GH) cutting it to just under seven minutes.
CJC-1295 has shown to reduce the production of the DPP-IV enzyme. This results in a feedback loop where the half-life GH and IGF-1 is prolonged and last more than seven days after administration on animal test subjects.
● Sensitivity, soreness, or pain at the injection site.
● Flu-like symptoms.
● Hives or other skin reactions.
The mechanism of action of CJC-1295 peptide shows how it can dramatically increase Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1)’s half-life which in turn elevates the processes which involve GH and IGF-1. Below are some of these effects:
Increased Protein Synthesis. The prolonged half-life of GH and IGF-1 caused by CJC-1295 has been found to increase the rate of protein synthesis in animal subjects. This results to significant growth in their muscle size and muscle mass over time.
Increased Bone Density. The increase in protein synthesis has been found to have a role in boosting bone density. Animal subjects have shown to have higher mineral matter per square centimetre in their bones after they are given CJC-1295.
Decreased Body Fat. The effect of CJC-1295 on DPP-IV and GHRH has also been found to play an important role in lipolysis or the reduction of body fat. It has been found to increase lipolysis in test subjects thus reducing their total body fat.
Improves Quality of Sleep. Although there is no way to quantitatively measure the quality of sleep animal subjects gets, this effect is based on the reasoning that the elevated rate of protein synthesis is compensated by an elevated amount of deep sleep as well.
If you’re new to CJC 1295, and use of growth hormones in general, you’re probably wondering how soon until you’ll begin to see the results. This is a common question that CJC 1295 users have. Several factors will contribute to how quickly you’re going to see results. Age, your genetics, lifestyle, health levels, external factors, and other supplements or prescriptions you are currently taking, are all going to impact how quickly you’ll experience the results of injecting CJC 1295.
It will usually take a few weeks before users are going to notice any real impact or difference in how they feel/appearance with CJC 1295. So, those who are looking for a “quick fix” aren’t going to get it here. It requires some time for the injection to acclimate with the body. And, if there are other medications or supplements in the system, this can further prolong how much time is going to be required in order to see the results of CJC 1295.
And, it’s important to note, the results will vary for each user. Some people might experience results in one week; especially those who are fit and workout regularly. A person trying to lose 100 pounds, who hasn’t worked out in years, might require a little more time to notice the results they expect to see when incorporating the growth hormone injection into their dietary regimen.
Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg. There was evidence of a cumulative effect after multiple doses.
CJC-1295 DAC is a long-acting version of GHRH (Growth Hormone Releasing Hormone) which has had its half-life extended to 8 days. This is convenient as it means the product only needs to be injected once or twice per week for continuously elevated levels of Human Growth Hormone (HGH) and IGF-1. The advantage of using CJC-1295 DAC instead of actual HGH injections is that injecting HGH shuts down the body’s own natural production and therefore when injections are ceased, the body’s ability to produce its own Growth Hormone may be impaired and take some time to recover. Since CJC-1295 DAC only stimulates the body’s own GH production, this risk is not apparent.
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