S4 Anadrine

S4 is also called Andarine or Acetamidoxolutamide. It is a type of SARMs (Selective Androgen Receptor Modulator) that is marketed as a potent muscle mass developer whilst being able to strip fat at the same time. Enough of the science lesson, now let’s see what this bad boy performing enhancing drug (PED) is all about..




Andarine works by binding to androgen receptors (in muscle tissue and bone tissue) which encourages your body to grow muscle. As a by-product of this, you’ll get stronger in the gym, you’ll be able to lift more and recover faster which will lead to yet more muscle gain.

Andarine S4 has been through human trials but no studies were published. There is some limited information which suggests that S-4 was described as the ideal SARM due to its single-day dosing, complete oral bioavailability and significant anabolic effects.

There are 3 different types of ‘chemicals’ that bind with the androgen receptors, these are as follows:

1. The androgen receptor ‘antagonists’ prevent the chemicals from activating
2. ‘agonists’ helps the chemicals to bind and detach e.g. testosterone
3. ‘modulators’ changes its structure and can react in a different way.

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S4 attaches itself to the androgen receptors and sticks to it like glue. This process exclusively creates more bone and muscle tissue growth. Therefore S4 is a type of SARMs that does attach itself to androgen receptors; this is very similar to other performance-enhancing drugs. The only difference is that S4 is extremely selective about its anabolic activity. Let’s take this a step further…

How it works?

We have established that SARMs work by binding themselves to androgen receptors and this is a major catalyst for anabolic activity within the body. During this process, more anabolic hormones are released and more protein can be utilised as building blocks. This triggers an increase in muscle mass, which is good news if you are on the gain’s train! The process is very similar to the way that steroids work but without the nasty side effects (the side effects of S4 will be discussed further on in the article).

Andarine has a very high androgenic impact on the body. Studies have shown that it has about 30% of the overall strength of testosterone when binding to the androgen receptors (1). Therefore S4 boosts the number of muscle gains by desensitising the androgen receptors. This, in turn, frees up the testosterone to perform its anabolic magic e.g. building new muscle tissue and burning body fat.

Side Effects

The big hitter when taking Andarine is that it can cause issues within the eyes. A lot of individuals report altered colour perception and night time blindness. The main cause of this is S4 binding to the eye receptors. However, these conditions are not permanent and eyes will return back to their normal state of health.

More information

Here are the absorbed benefits of S4
● Very limited growth on tissues of the major organs e.g. prostate, heart, liver and kidneys
● There is no significant change in the LDL/HDL ratio- this makes it is a very low cardiovascular risk
● No chance of female characteristics e.g. man boobs, developing in the post cycle recovery stage
● There is no reduction in testosterone during the post cycle recovery
● It does not require a lengthy post-cycle recovery- 4 weeks is a good time span
● It increases muscle mass and reduces % body fat.


If you do decide to give S4 a shot- then consume 2 x 25mgs doses on a daily basis for 12-16 weeks. S-4 does not need to be taken on 3 separate occasions throughout the day. Try to consume S4 with main meals. Complete a 4-week cycle and give your body a 4-week flush before starting another cycle.

In terms of gaining muscle, Andarine does have a diminishing point. If your daily dose over 75 mg for more than 16 weeks, this will have no significant impact on your gains. There will be no added side effects at higher doses. But you do run the risk of lowering the amount of free testosterone during the post cycle flush!
Andarine does seem to work more effectively when combined with other types of SARMs. Fundamentally it does work well with both MK-2866 and LGD 4033. Both of these SARMs suppress testosterone levels at higher dosages and S4 does seem to stop this from happening.


Andarine was extremely popular before the Beijing Olympics in 2008. In 2008 SARMs were ultimately banned for professional athletes by WADA. However, if you an amateur bodybuilder and want to pack on some muscle mass; get lean without damaging your health…then why not give S4 a go!

User reviews

Review 1
I love andarine s4, it’s like using Winstrol without having to buy steroids on the black market or worry about UG labs. However, just like with everything, with a lot of good, there is always a bit of
bad. With andarine (s4) the biggest issue (besides the awesome results and gains) is the minor vision side effects you get. But…how do you mitigate these side effects?

Review 2
RAD-140 and nutrobal are also worth considering.

Review 3

Felt tired and worn out but once I started stacking cardarine with other substance, I was unstoppable. Cardarine cycle turned me into a hulk and gave me long-lasting stamina.


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