Ostarine (MK-2866) is a SARM developed by GTx for the prevention and treatment of muscle wasting. It may eventually be a medical prescription for the prevention of cachexia, atrophy and sarcopenia as well as for Hormone or Testosterone Replacement Therapy.




As a research chemical, Ostarine belongs to a class of chemicals know as SARMS or selective androgen receptor modulators. SARMS create selective anabolic activity at certain androgen receptors. In comparison to testosterone and other anabolic steroids, the advantage of SARMS, is they do not have androgenic activity in non-skeletal muscle tissues. Ostarine is effective in maintaining and increasing lean body mass.

They have a number of benefits, including:
  • Promote Lean Muscle Growth.
  • Enhance Athletic Performance.
  • Increase Strength Gains.
  • Encourage Fat Loss.

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How it works?

ARMS bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity.

Androgen receptor activation
Binding and activation of the Androgen receptor alters the expression of genes and increases protein synthesis which builds muscle. In essence, SARMS like Ostarine cause muscle growth in the same manner as steroids, however unlike testosterone and other anabolic steroids, SARMS do not produce the growth effect on prostate and other secondary sexual organs.

Ostarine, in particular, exerts its anabolic effects on muscle tissue almost exclusively. So not only does it represent a new potential treatment option for a wide spectrum of conditions from muscle wasting diseases (from age-related to AIDS or cancer-related), but is also has immense potential for muscle building for bodybuilders, fitness, athletes and an agent to minimize atrophy during recovery periods from serious surgery or similar situations.

Side Effects

SARMS do not aromatize, conferring all their effects to AR binding and not to metabolic conversion to active androgens/estrogens. However, blood work from users has shown a slight elevation in serum estradiol levels (which may be one of the factors in its high effectiveness for treating tendon, ligament, and bone injuries or illnesses.

This elevation is extremely small and is no cause for concern. If however, you are absolutely concerned about slight increases in Estrogen, you can always opt for low doses AI’s, like Aromasin or Arimidex for added protection and prevention.

More information

● It is non-methylated so it is non-toxic to the liver or blood pressure
● Some suppression may be present at doses of 25mg+ run for longer than 4 weeks, however, a stringent PCT of prescription SERMs like Nolvadex or Clomid is not necessary.
● High oral bioavailability without significant damage to your liver as with oral steroids.
● Great sense of well being while on, (without the aggression which can often detrimentally impact users daily lives).
● No need for a long time period off between cycles; the recommended time of period for normal steroid cycles would be Time on + PCT, so for a typical 6-week cycle and 4 week PCT, a user would have to wait another 10 weeks after PCT to start another cycle where SARMS recovery requires minimal rest in between.
● Ostarine also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk category – hence there is little impact on cholesterol values.


As Ostarine has a half-life of around 24 hours, each of these doses only has to be taken orally once a day, therefore its also offers an extremely convenient supplementation intake.


Ostarine does not have the harsh effects on users internal organs, and it also does not convert to estrogen. These are large benefits when users are considering doing an Ostarine cycle. As MK-2866 works to prevent muscle wasting, that makes it a great tool during a cutting cycle.

User reviews

Review 1
Ostarine has been the saviour for my elbows. It’s been like two weeks since I started with N2Joints Rx, and my elbows are getting even better. Also, with this combo, I noticed, that my knees don’t hurt me after long runs. These two are some truly amazing joint supplements.

Review 2
So I took the full dose of 25mg, exactly 9 am. Didn’t get any of the side effects some people reported such as headaches or sudden hunger but could be because I’m feeling a bit rough already so was already experiencing headaches before I took it.

The first time I did notice the effect was when I went to the gym. Bearing in mind this week will be my second week back after 2 months off, I didn’t get any fatigue at all. I did the same workout as I did last week for chest and tri’s which left me crippled to say the least, and the pump is incredible.

Review 3

I am getting close to the end of a 12 week cycle of 30mg.
Here is the thing:
It will take 3 weeks before this starts to kick in for real.
It will not help you if you do not work out and do so hard.
If you are an intermediate or advanced lifter, that follows a real program with high volume this will be a godsend.
The recovery is insane!
I work out 6 days/week, T1 is Wendlers 531, T2 is Sheiko + accessories.

This allows me to put in amazing volume and be good to go the next day.

It does not make you much stronger, but it lets you recover over night from pretty much everything, so combined with a good program you will grow.

Slightly supressive, some light mood swings, especially the first 3-4 weeks.
Joint pains first 3 weeks that then dissapears.

Since this has been a Iong cycle, I will follow it with 1 month of clomid 25mg every day, seems to be the recommended PCT.

Review 4

I got ostarine for my wife as she wanted more lean muscle and lower body fat.
This product does exactly that.
In 2 weeks she dropped 4kg but her traps delts and arms literally popped.
She looks and feels great.


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