MGF (C-terminal)

Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue. It’s called MGF as IGF-IEa is a bit of a mouthful and harder to identify amongst the other IGF variants.





What makes MGF special is its’ unique role in muscle growth. MGF has the ability to cause wasted tissue to grow and improve by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth. MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-1 receptor domain which, in turn, increases protein synthesis turnover; therefore, if used correctly it can improve muscle mass over time.

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How it works?

When you train, what happens to your muscles is they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant. The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die.
As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair, if the cells are not repaired they die and your muscles get smaller and weaker. In muscle tissue, the pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.

Now, with synthetic injections of MGF, you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. In terms of dosages, 200mcg bi-laterally is the very best choice of dosing in muscles trained.

The only problem with MGF, and this is the reason I don’t like it, is that it has such a short half life, just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn’t been damaged. That’s why, for me personally, I think the best option is PEG-MGF

Nevertheless, MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is EXTREMELY anabolic.

Side Effects

Side effects of MGF are missing, which means that official data are rare. Pain or irritation in the injected area are the most common complaints that usually refer to the sore or itchy feeling of the injection site.

More information

Running PEG MGF in synergy with IGF is perfect but there are things you need to know. Since IGF has such strong receptor affinity, if you dose them at the same time, the effectiveness of MGF will just be wasted, at least on paper (the science supports this claim). However, further trials that I, and others, have conducted leads this to being inconclusive.


Dosing 3 times a week as suggested above, and 1ml of BA water for every 2mg is optimal. Storage in the fridge for up to 6 months. Avoid exposure to heat or sunlight.


The use of synthetic MGF increases muscle growth by hyperplasia (cell division) and hypertrophy (cell growth). The peptide affects not only the growth of muscle tissue but also has an effect on the burning of body fat, which in muscle growth cycles let this to be in a much easier way. MGF increases endurance, rapid recovery after exercise and increases vascularization. As a further effect, the user will notice that his immune system is much higher and that the new cholesterol is low to the minimum. MGF also helps regenerate all tissues in the body, not just muscle tissue, it is a very good half-life effect, given the frequent injuries of sportsmen.

User reviews

Review 1
Over a 4 week run, I noticed about 4lb increase with the PEG MGF and LR3 partnership, and roughly the same weight in fat loss, very impressive. Though, some of my clients have noted far greater increases in muscle mass. If you’re on a steroid cycle, there is no need for the addition of DES as IGF levels will already be elevated; you’re better off with MGF, PEG MGF can take your recovery and gains to a new level.

Review 2

Excellent product. Highly recommended.


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