The delta-sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.




The influence of delta sleep-inducing peptide (DSIP) on sleep was studied in 16 chronic insomniac patients according to a double-blind matched-pairs parallel-groups design. Subjects slept for 5 consecutive nights in the laboratory. Night 1 was used for adaptation, night 2 for baseline measurements. In the afternoon before the 3rd, 4th and 5th night, half of the patients received intravenously 25 nmol/kg body weight DSIP, and half of the patients a glucose solution (placebo). Measures for sleep structure, objective (polysomnography) and subjective sleep quality and for subjective tiredness were assessed. The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo. One measure of subjectively estimated tiredness decreased within the DSIP group. Data analysis suggested, however, that the statistically significant effects were weak and in part could be due to an incidental change in the placebo group. As none of the other measures, including subjective sleep quality, showed any change, it was concluded that short-term treatment of chronic insomnia with DSIP is not likely to be of major therapeutic benefit.

Its amino acid sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, the gene is unknown[citation needed], raising serious questions regarding the actual existence of this peptide in nature.

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How it works?

Summing up all these separate and contradictory data, one can suggest that endogenous DSIP [or DSIP‐like peptide(s)] is nothing but a previously unknown humoral regulator of the body carrying out various functions, the role of a hypothalamic ‘trophotropic hormone’ and stress‐limiting factor being primary among them.

Side Effects

Perhaps the most intriguing actions of DSIP have been found with human beings. In all human trials, involving a total of more than 70 subjects, no adverse side effects (cardiovascular, respiratory, metabolic) of DSIP have been observed. Besides some symptoms like headache and some other particular reactions (vomiting, vagal reaction, hypotension, discomfort and arousal: one case each) of addicts being withdrawn from alcohol and opiates, DSIP
was always well tolerated during administration.

More information

● Can act as a stress limiting factor.
● May have a direct or indirect effect on body temperature and al eviating hypothermia.
● Can normalize blood pressure and myocardial contraction
● It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.
● There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion[and suppression of paradoxical sleep, (PS) while some studies show no correlation. Stronger effects on sleep have been noted for the synthesized analogues of DSIP.
● It may affect human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis.

Review 1

I have been testing this through a lab rat and it works amazing!!!!!!! I believe there is a massive gh output through some channels. Body comp changing amazing fast and sleeping better than ever.

Review 2

well, i was having major sleeping issues and always been kind of down. And this is making a world of difference. Stress free all day long, sleep like a baby. Just need to take energy supplements to stay alert during day.

Review 3

Sounds like a negative to me if it is preventing REM sleep.



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