Dutasteride

Dutasteride (Avodart), an oral synthetic 4-azasteroid, is a potent, selective, irreversible inhibitor of type 1 and type 2 5alpha-reductase (5AR), the enzyme that converts testosterone to dihydrotestosterone (DHT) intracellularly. Although type 2 5AR predominates, both isoenzymes are overexpressed in prostate tissue in benign prostatic hyperplasia (BPH) and at all stages in some prostate cancers.

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Description

Introduction

Dutasteride is used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Dutasteride helps improve urinary flow and may also reduce your need for prostate surgery later on.
dutasteride is for use in men only.

Dutasteride may also be used for purposes not listed in this medication guide.

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How it works?

Dutasteride belongs to a class of drugs called 5 alpha-reductase inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
There’s a hormone in your blood called dihydrotestoterone (DHT) that causes your prostate to grow. Dutasteride prevents the formation of DHT in your body, causing an enlarged prostate to shrink.

Side Effects

The more common side effects that can occur with dutasteride include:
● trouble getting or keeping an erection
● A decrease in sex drive
● ejaculation problems
● A decrease in sperm count and activity

These effects may continue after you stop taking dutasteride.

More information

Dutasteride should never be taken by a woman or a child.
Dutasteride can cause birth defects if a woman is exposed to it during pregnancy. Dutasteride capsules should not be handled by a woman who is pregnant or may become pregnant.

Dosages

Adult dosage taken alone and in combination with tamsulosin (ages 18 years and older)
● Typical dosage: One 0.5-mg capsule per day.
● Child dosage (ages 0–17 years)
Dosage for people younger than 18 years old hasn’t been established.

Conclusion

Pharmacotherapeutic group: testosterone-5-alpha-reductase inhibitors. ATC code: G04C B02. Dutasteride reduces circulating levels of dihydrotestosterone (DHT) by inhibiting both type 1 and type 2, 5α-reductase isoenzymes which are responsible for the conversion of testosterone to DHT.

User reviews

Review 1
dutasteride is awesome! been using it for 2 years. prostate is tiny now. hairline is growing back, body hair is reduced, although I didn’t have that much before. Sexual side effect, semen volume is definitely reduced, however no problems with erection or orgasm when I have a stimulating subject

Review 2
I have found dutasteride highly effective at treating symptoms of my enlarged prostate but it is a long term drug. It took me about 2 months to start seeing an improvement in my bph symptoms and I really noticed major improvement by month 5. So I’m glad I stuck to my doctor’s advice to give it time. She also went over the side effects very carefully with me noting it can be a good drug for some men and a poor drug for others. What discourages a lot of men is that while the beneficial take months the side effects hit you after a few days. A reduction in sexual interest will happen. You need to consider that ahead of time before going on it. If you currently enjoy a good sex life you should avoid this drug if possible. But if you are in a sexless marriage like me- fairly common by the bph age, then maybe the side effects are welcome. In my case my wife is in menopause and I like my decreased desire.

Review 3

My father was on this medication as well as flomax for a couple months, at best. Within days of him taking these, he had complaints of lost of taste. His appetite diminished, and he lost about 30 pounds. His primary care doctor recommended cutting out the Flomax which did not change anything. Next, we cut out Advodart and he’s slowly (very slowly) starting to taste certain items again. The urologist gave us the “in 20 years of prescribing this medication, I’ve never heard of that”, and basically that it was not the cause, merely a coincidence. I understand half lives and that the medication ‘should’ be out of his system within days, but it’s only common sense that not everyone’s body is going to react the same. I’m looking for a new urologist to say the least.

Review 4

It caused me to have really big acne blisters on right above my cheekbones (a little towards the ears side). And this would happen every third day I took the avodart 0.5 pill (I started it with once a week). I left it for a few weeks to see if it really was the avodart which was causing this reaction. And no new pimples or blisters. And when I tried that again a month later the same happened. So that confirmed that avodart was indeed the cause. It gave me a few tiny acne scars too

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