SEROSTIM is a human growth hormone (hGH) produced by recombinant DNA technology. SEROSTIM has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary growth hormone.
SEROSTIM is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the hGH gene. SEROSTIM is secreted directly through the cell membrane into the cell-culture medium for collection and purification.
SEROSTIM is a sterile lyophilized powder intended for subcutaneous injection after reconstitution to its liquid form.
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How it works?
SEROSTIM is an anabolic and anticatabolic agent which exerts its influence by interacting with specific receptors on a variety of cell types including myocytes, hepatocytes, adipocytes, lymphocytes, and hematopoietic cells. Some, but not all of its effects, are mediated by insulin-like growth factor-1 (IGF-1).
What are the most common side effects of SEROSTIM reported in clinical trials in patients treated for HIV-associated wasting or cachexia?
● Swelling, especially in the hands or feet or around the eyes
● Bone, muscle, and joint pain or stiffness
● Tingling, numbness and pain in the fingers, thumb or wrist
● Unusual skin sensations
● Breast enlargement in men
● Extreme tiredness
Other less common but serious side effects of SEROSTIM are:
● High blood sugar (hyperglycemia/diabetes) which can include symptoms of increased thirst and urination, tiredness, or trouble concentrating
● Headaches, changes in vision, nausea or vomiting, which requires immediate medical attention
● Serious allergic reactions that require immediate medical attention
● Pain and tenderness in the abdomen
These are not all of the possible side effects. Let your doctor know about any side effects you experience. Your doctor may prescribe a pain reliever or may decrease your dose of Serostim to help manage some side effects.
Serostim is recombinant (made in a lab) human growth hormone for treatment of HIV wasting (unintentional loss of weight) or cachexia (general ill health resulting from emaciation), decreased lean body mass (muscle), and loss of physical endurance. Loss of muscle can be difficult to notice or diagnose. Serostim has been shown to increase HIV replication in the test tube; therefore, patients must be taking anti-HIV therapy, known as HAART (or cART), in order to be prescribed Serostim.
1 mg/kg via subcutaneous (under the skin) injection, which may be in the thigh, upper arm, abdomen, or buttock once daily at bedtime (up to 6 mg), rotating injection sites and avoiding scar tissue, bruises, and the navel. It is available in 4 mg, 5 mg, and 6 mg vials. The multi-use 4 mg vial is reconstituted with bacteriostatic (containing a biological or chemical agent that stops bacteria from reproducing) water for injection and may be refrigerated for up to 14 days after reconstitution. The single-use 5 mg and 6 mg vials are reconstituted with sterile water for injection and must be used immediately; after administering the dose, any unused portion should be discarded. Some loss of the dose can be expected (approximately 10%). Inject the water into the vial aiming for the glass wall. The vial should be swirled gently in a circular motion until solution is completely dissolved; it must be clear and colorless. Do not shake. Do not inject if solution is cloudy or contains particles.
SEROSTIM is a human growth hormone (hGH) produced by recombinant DNA technology. SEROSTIM has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary growth hormone. SEROSTIM is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the hGH gene. SEROSTIM is secreted directly through the cell membrane into the cell-culture medium for collection and purification.
Serostim worked for 12 years but does not seem to help now.