Tev-Tropin HGH

Tev-Tropin [somatropin (rDNA origin) for injection], a polypeptide of recombinant DNA origin, has 191 amino acid residues and a molecular weight of about 22,124 daltons. It has an amino acid sequence identical to that of human growth hormone of pituitary origin. Tev-Tropin is a strain of Escherichia coli modified by insertion of the human growth hormone gene.

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Description

Introduction

Tev-Tropin is a sterile, white, lyophilized powder, intended for subcutaneous administration, after reconstitution with the accompanying diluent.

Tev-Tropin is indicated for the treatment of children who have growth failure due to an inadequate secretion of normal  endogenous growth hormone.

Benefits –

  • Skeletal Growth. Tev-Tropin® stimulates skeletal growth in patients with growth hormone deficiency. …
  • Cell Growth. It has been shown that there are fewer skeletal muscle cells in short statured children who lack endogenous growth hormone as compared with normal children. …
  • Organ Growth.

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How it works?

Clinical trials have demonstrated that Tev-Tropin is equivalent in its therapeutic effectiveness and in its pharmacokinetic profile to those of human growth hormone of pituitary origin (somatropin). Tev-Tropin stimulates linear growth in children who lack adequate levels of endogenous growth hormone. Treatment of growth hormone-deficient children with Tev-Tropin produces increased growth rates and IGF-1 (Insulin-Like Growth Factor-1) concentrations that are similar to those seen after therapy with human growth hormone of pituitary origin.

Both Tev-Tropin and somatropin have also been shown to have other actions including:

Tissue Growth

Skeletal Growth. Tev-Tropin stimulates skeletal growth in patients with growth hormone deficiency. The measurable increase in body length after administration of Tev-Tropin results from its effect on the epiphyseal growth plates of long bones. Concentration of IGF-1, which may play a role in skeletal growth, are low in the serum of growth hormone-deficient children but increase during treatment with Tev-Tropin. Mean serum alkaline phosphatase concentrations are increased.

Cell Growth.
It has been shown that there are fewer skeletal muscle cells in short statured children who lack endogenous growth hormone as compared with normal children. Treatment with somatropin results in an increase in both the number and size of muscle cells.

Organ Growth. Somatropin influences the size of internal organs and it also increases red cell mass.

Side Effects

Headache, nausea, vomiting, fatigue, muscle pain, or weakness may occur. If these symptoms continue or become bothersome, inform your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: development of a limp, persistent fatigue, unusual/unexplained weight gain, persistent cold intolerance, persistent slow heartbeat, fast heartbeat, ear pain/itching, hearing problems, joint/hip/knee pain, numbness/tingling, unusual increase in thirst or urination, swelling hands/ankles/feet, change in the appearance or size of any mole, persistent nausea/vomiting, severe stomach/abdominal pain.

Get medical help right away if you have any very serious side effects, including: vision problems/changes, seizure, severe headache.

More information

Before using somatropin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as benzyl alcohol or metacresol found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Dosages

The recommended dosage of Tev-Tropin is up to 0.1 mg/kg (0.3 lU/kg) of body weight administered 3 times per week by subcutaneous injection. Tev-Tropin may interact with insulin or oral diabetes medicines, steroids, cyclosporine, seizure medication, birth control pills, anabolic steroids, or hormone replacement medications for men or women. Tell your doctor all medications and supplements you use. Tev-Tropin should be used only when prescribed during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Conclusion

Tev-Tropin [somatropin (rDNA origin) for injection] is a form of human growth hormone used to treat growth failure in children and adults who lack natural growth hormone and in those with chronic kidney failure Noonan syndrome Turner syndrome short stature at birth with no catch-up growth and other causes. Tev-Tropin is also used to prevent severe weight loss in people with AIDS or to treat short bowel syndrome.

User reviews

Review 1
My son is 13 and has been taking Tev-Tropin with the T-Jet device for nearly a year and he has not grown at all, maybe an inch.

Review 2
My son is 9 and has severe growth hormone deficiency. He has been taking Tev-Tropin for over 2 years now. He started out below the 3rd percentile in height and is now above the 25th percentile. He has a better appetite, and is doing great! We are so thankful for this medicine and have had no side effects to report.

Review 3

My son started nightly injections of Tev-Tropin just 5 weeks ago after being diagnosed with a growth deficiency. He is almost 13 years old. We measured this morning and he has growth 3/4 of an inch!

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