Clomiphene

Clomiphene is a non-steroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary).

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Description

Introduction

Clomiphene is used to cause ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent naturally occurring ovulation.

Clomiphene may also be used for purposes not listed in this medication guide.

This medication is used to treat infertility in women. It works by stimulating an increase in the amount of hormones that support the growth and release of a mature egg (ovulation). This medication is not recommended for women whose ovaries no longer make eggs properly (primary pituitary or ovarian failure).

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How it works?

clomiphene blocks the hormone estrogen from interacting with the pituitary gland. When estrogen interacts with the pituitary gland, less luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are produced.

This leads to a decrease in testosterone and therefore decreased sperm production. Because clomiphene blocks estrogen’s interaction with the pituitary gland, there’s an increase in LH, FSH, and testosterone in the body.

Side Effects

Common clomiphene side effects may include:
● flushing (warmth, redness, or tingly feeling);
● breast pain or tenderness;
● headache; or
● breakthrough bleeding or spotting.

More information

Do not use clomiphene if you are already pregnant.
You should not use clomiphene if you have: liver disease, unexplained abnormal vaginal bleeding, an uncontrolled adrenal gland or thyroid disorder, an ovarian cyst (unrelated to polycystic ovary syndrome), or if you are pregnant.

Dosages

Optimal dosing in males hasn’t been established. The dose given can range from 12.5 to 400 milligrams (mg) per day.
A recent review recommends a starting dosage of 25 mg three days per week and then slowly titrating — or adjusting the dosage — until the dose is 50 mg per day as needed.

Conclusion

Clomiphene is typically used as an infertility treatment in females. It’s not approved by the FDA for use in males, but it’s often prescribed off-label for the treatment of male infertility.
Taking clomiphene can lead to an increase in testosterone and sperm count. Studies on its efficacy in males have had mixed results.

User reviews

Review 1
I have been TTC for 2years,I took clomiphene for the first cycle, I didn’t get the positive result, I am on my second cycle with per day, hopefully it will work this time. The positive comments on here give me hope I will hold my babies too.I will keep you all posted

Review 2
Been trying to have a baby for Soo long and I got prescribed for clomiphene on my third day of my period on March so I missed my April periods just took a test this week on Monday and it was positive, it really works, I just took the dose once.

Review 3

I’m 29 and I have PCOS I got on clomid 50g in March on day 2-6 of my cycle (period induced with provera).Didn’t use the OPT(was too scared to go out during the lockdown) to time intercourse, we just tried to do it everyday. On day 35 of my cycle I got a positive pregnancy test after feeling sick for a week. It works, Good luck everyone

Review 4

After my 1st miscarriage, I took clomid 50mg for the first cycle, I didn’t get the positive result, then on 2nd cycle I took 100mg per day – guess what now I have a very cute baby boy and he is two years old now..

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