Pramipexole, or just Prami for short (brand names Sifrol, Mirapex, Mirapexin), is a dopamine agonist that is used in the medical community to treat Parkinson’s disease and RLS (restless legs syndrome). It has also been found to be helpful in the treatment of bipolar and unipolar depression. Additionally, it is still being researched for its ability to treat certain types of headaches, and helping antidepressant users who are experiencing sexual dysfunction.




Pramipexole is used alone or with other medications to treat Parkinson’s disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move (“on-off syndrome”).

However, this compound is also used in the bodybuilding community because of its ability to affect dopamine and prolactin. This makes it an interesting ancillary, for both on cycle and post cycle use.

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How it works?

Pramipexole can inhibit prolactin, and in order to fully understand how this benefits the user, we must first take a look at what prolactin is.

Prolactin is a nasty female hormone protein, whose levels increase during pregnancy. Yet, in spite of the fact that it is mostly associated with women, prolactin is also found in men as it spikes after ejaculation and after having children. Interestingly, researchers still do not know why mother nature gave males prolactin, but we can theorize it is likely due to keeping human population under control. When a male ejaculates after sex, he gets satisfied thanks to changes in both prolactin (which rises), and dopamine (which falls). After this occurs, males will lose interest in sex for a period of time. As a matter of fact, this is why men want to get away from women after we have sex with them.

Side Effects

This point of no interest in sex by males is what we call the ‘refractory period,’ and until prolactin starts to drop back down, the male will not have as much interest in sex. However, pramipexole will inhibit prolactin from rising, making a man’s refractory period be much shorter. As a result, you can expect libido (the urge for sex) to be more frequent when using this compound. Therefore, these types of prolactin inhibitors are great to take with you on your honeymoon!

Now how does this translate into bodybuilding or fitness? Scroll down to find out, but first lets take a look at dopamine.

More information

By now, you might be asking yourself – how does keeping prolactin down and dopamine up help us as athletes?
To answer this question, lets start first with dopamine: if we do not feel the need to bite into that pizza or eat that candy bar, it can help keep appetite under control. Since athletes always want to eat clean, this is a good thing, as it makes dieting so much easier.

Now it is the turn of prolactin: when a bodybuilder runs certain anabolic steroids that are progestin based (like trenbolone), they can get a rise in prolactin levels, which contributes to a loss of libido and many other side effects. For instance, many times we have seen gynecomastia (gyno) develop due to trenbolone use, and that is because the user abused the steroid for long periods of time without controlling prolactin levels. Luckily, pramipexole (prami) will help inhibit this prolactin rise, and avoid side effects associated with this hormone.

What’s more, no matter what the athlete may use as far as anabolic steroids, there is always going to be that coming off part, where they sometimes have a massive drop in libido. Therefore, it is important to use pramipexole during post cycle therapy (PCT) and/or bridge, as it can help keep libido strong until the HPTA reaches homeostasis. In fact, this is the reason why many of those who cycle steroids will use prami during, or after cycle. In addition to that, prami may be used by those who just want sexual benefits or help with appetite suppression.


Pramipexole dosages should be very conservative. I have read online that some say to run it twice per day, or recommend to run it at too high of a dose. Obviously, this is bad advice, and it will cause side effects. Hence, I recommend to dose it every other day, and start with only 0.06 milligrams (mg), before slowly working your way up to 0.25mg.

Pramipexole is a pricey drug, but it is still cheaper than cabergoline. It’s only cheaper because of the crazy side effects.


Due to its side effects and shorter half life vs. its main competitor cabergoline/dostinex, pramipexole has mostly been abandoned by research chemical sites. However, you can still find it if you really want to.

User reviews

Review 1
I have taken this medication for 11 yrs and it almost has destroyed my life!! I slowly came off of this drug , I was taking 3 mg, and should have never been on that strong of a dose!! What it does to the brain is feed it a fake dopamine and that is really bad!! If it not been the herbal extracts ashwagandha, and rhodiola they have a natural dopamine that has just recently helped me get off this medication. I take it a couple of times a day and Thank GOD I am getting better every day and taking back my life!! Trust me when I say I had severe RLS!

Review 2
I took pramipexole for 9 days. It made me drowsy, dizzy, and very hungry.

Review 3

Pramipexole keeps me awake

Review 4

Restless leg syndrome seems to run in my family. My sister tried this medication and has never looked back, my dad asked his dr if he could try it and he also has never looked back. So it was my turn, I asked my dr and she was fine about prescribing it as it’s not only for Parkinson’s desease it’s been used for restless leg syndrome and results have been good. Well I was absolutely astonished! It worked and I sleep all night and feel great the next day, first in a long time!


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