Dapoxetine

Dapoxetine, a new antidepressant, has been found to be safe and effective for the treatment of premature ejaculation, according to two major clinical trials. Dapoxetin is a short-acting selective serotonin reuptake inhibitor (SSRI).

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Description

Introduction

Dapoxetine is a selective serotonin reuptake inhibitor medicine which has specially been developed for the treatment of premature ejaculation. It increases the time it takes to ejaculate and can improve the control over the ejaculation. It starts to work very quickly, so it is taken when you anticipate having sex, rather than every day. You have to take it 1-3 hours before you have sex.

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How it works?

The drug’s mechanism of action is thought to be related to inhibition of neuronal reuptake of serotonin and subsequent potentiation of serotonin activity. The central ejaculatory neural circuit comprises spinal and cerebral areas that form a highly interconnected network. The sympathetic, parasympathetic, and somatic spinal centers, under the influence of sensory genital and cerebral stimuli integrated and processed at the spinal cord level, act in synergy to command physiologic events occurring during ejaculation. Experimental evidence indicates that serotonin (5-HT), throughout brain descending pathways, exerts an inhibitory role on ejaculation. To date, three 5-HT receptor subtypes (5-HT(1A), 5-HT(1B), and 5-HT(2C)) have been postulated to mediate 5-HT’s modulating activity on ejaculation.

Side Effects

The most common side effects included yawning, nausea, dizziness, and headache. No severe side effects, such as self-harming or aggressive behavior, serotonin syndrome, postural hypotension, or syncope, were reported.

More information

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking dapoxetine it is important that your doctor knows:
● If you have a tendency to faint.
● If you have a heart condition.
● If you have a bleeding or clotting disorder.
● If you have epilepsy.
● If you have ever had a mental health problem causing ‘high’ or ‘low’ moods, such as bipolar disorder, depression or mania.
● If you have increased pressure in your eye, a condition called glaucoma.
● If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.

Dosages

Take dapoxetine exactly as your doctor tells you to. Drink a full glass of water at the same time as you take a tablet. The recommended starting dose is one 30 mg tablet, taken 1 to 3 hours before you anticipate having sex. Your doctor may later decide to increase your dose to one 60 mg tablet. Your doctor will only prescribe the higher dose for you if the 30 mg dose is insufficient, and providing you have not experienced any side-effects such as feeling faint.

Conclusion

Dapoxetine, which is generally categorized as a fast-acting SSRI, was developed specifically to treat this condition. It may be effective at the first dose (ie, on demand) when given 1-3 hours before sexual intercourse, and its adverse-effect profile is comparable to those of other SSRIs. Dapoxetine has been approved in a number of countries but not yet in the United States. In a study of men with both premature ejaculation and erectile dysfunction who were on phosphodiesterase type 5 (PDE5) therapy, dapoxetine provided treatment benefit and was generally well tolerated. However, up to 90% of patients discontinue dapoxetine, mostly because of adverse effects, cost, and disappointing efficacy.

User reviews

Review 1
Was very impressed with these, worked well. Very happy

Review 2
Very very effective. Amazing results. Sometimes get a touch of diarrhoea but not often. Take with a pint of water. Can govat it for an hour now! Perfect. And my partner thinks it’s incredible.

Review 3

The medication definetely helped delay the time to ejaculation, and i felt more (although not completely) in control of when i ejaculated. My OH did notice that sex lasted several minutes longer. Will be ordering again to see for any onger term effects on my staying, but even if there are none, the medication works when i have it.

Review 4

Very very effective. Amazing results. Sometimes get touch of diarrhoea but not often. Take with a pint of water. Can govat it for an hour now! Perfect. And my partner thinks it’s incredible!

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